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Mirc30 Complex/Cluster/Region Detail
Summary
  • Symbol
    Mirc30
  • Name
    microRNA cluster 30, including Mir16-1 through Mir15a
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:5315448
  • Cluster Members
    Mir16-1, Mir15a (2 members)
Location &
Maps
more
  • Sequence Map
    Chr14:61869329-61869559 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
Human Diseases
more
  • Diseases
    1 with Mirc30 mouse models

Human Disease Mouse Models
      
IDs
 View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in hematopoietic cells exhibit chronic lymphocytic leukemia with increased B cell numbers, increased spleen weight, and a partial block to NK cell development.
Other Database
Links
less
miRBase MI0000564, MI0000565
References
more
  • Summaries
    All 24
    Diseases 3
    Phenotypes 23
  • Earliest
    J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
  • Latest
    J:345510 Zhou C, et al., Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia. Adv Sci (Weinh). 2022 Jun;9(17):e2104986
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory