Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2tm1.1Sjk
Name:	B cell leukemia/lymphoma 2; targeted mutation 1.1, Stanley Korsmeyer
MGI ID:	MGI:5313428
Synonyms:	Bcl2AAA, Bcl2tm1.1Blev
Gene:	Bcl2  Location: Chr1:106465908-106642004 bp, - strand  Genetic Position: Chr1, 49.76 cM
Alliance:	Bcl2tm1.1Sjk page

Germline Transmission:	Earliest citation of germline transmission: J:181308
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Nucleotide substitutions in exon 2 were used to replace the threonine at 69 and serines at positions 70 and 84 with alanines (T69A, S70A and S84A). Flp-mediated recombination removes the puro cassette inserted downstream of the modified exon 2. (J:181308)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:	41 strains or lines available

Original:	J:181308 He C, et al., Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012 Jan 26;481(7382):511-5
All:	8 reference(s)