Analysis Tools
mortality/aging
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• mice show a trend of exacerbated mortality compared to single Tg(APPV717F)109Ili expressing mice
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Allele Symbol Allele Name Allele ID |
Bcl2tm1.1Sjk targeted mutation 1.1, Stanley Korsmeyer MGI:5313428 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show a trend of exacerbated mortality compared to single Tg(APPV717F)109Ili expressing mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased exercise endurance
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• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice
• however, basal levels of autophagy are normal
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• in mice fed a high-fat diet with no drop in levels following exercise unlike in wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit an increase in carbon dioxide production unlike wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit an increase in oxygen consumption unlike wild-type mice
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• mice exhibit impaired exercise-induced increase in insulin sensitivity compared with wild-type mice
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• exercised mice fail to exhibit a decrease in circulating glucose levels compared with wild-type mice
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• exercised mice exhibit less of a reduction in plasma insulin levels compared with wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit protection from impaired glucose tolerance compared with wild-type mice
• however, mice fed standard chow exhibit normal glucose tolerance
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• exercised mice fed a high-fat diet fail to exhibit an increase in adiponectin levels unlike in wild-type mice
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• exercised mice fed a high-fat diet exhibit less of a decrease in cholesterol levels compared with wild-type mice
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• exercised mice fed a high-fat diet exhibit less of a decrease in triglyceride levels compared with wild-type mice
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• exercised mice fed a high-fat diet fail to exhibit an increase in heat production unlike wild-type mice
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• reduced in starved mouse embryonic fibroblasts and skeletal and cardiac muscles or skeletal muscles from exercised mice
• however, basal levels of autophagy are normal
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• impaired in exercised mice
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• exercised mice fed a high-fat diet exhibit less of a decrease in percent fat mass compared with wild-type mice
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| N |
• baseline cardiac and skeletal muscle properties are normal
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• impaired in exercised mice
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• decreased exercise endurance
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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