Ift140tm1b(KOMP)Wtsi
Targeted Allele Detail
|
|
| Symbol: |
Ift140tm1b(KOMP)Wtsi |
| Name: |
intraflagellar transport 140; targeted mutation 1b, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:5311831 |
| Synonyms: |
Ift140null1 |
| Gene: |
Ift140 Location: Chr17:25235056-25318461 bp, + strand Genetic Position: Chr17, 12.53 cM
|
| Alliance: |
Ift140tm1b(KOMP)Wtsi page
|
| IMPC: |
Ift140 gene page |
|
| Mutant Cell Lines: |
EPD0073_5_F01, EPD0073_5_G01 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:181533
|
| Parent Cell Line: |
JM8.F6 (ES Cell)
|
| Strain of Origin: |
C57BL/6N
|
| Project Collection: |
KOMP-CSD
|
|
| Allele Type: |
|
Targeted (Null/knockout, Reporter) |
| Mutations: |
|
Insertion, Intragenic deletion
Vector: L1L2_Bact_P
|
| |
|
Mutation details: The L1L2_Bact_P cassette was inserted at position 25168608 of Chromosome 17 upstream of the critical exon(s) (Build 37). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 7 at position 25169359. Exon 7 is thus flanked by loxP sites. Cre expression excised exon 7 and the neomycin selection cassette resulting in the creation of a reporter knockout mouse.
(J:148605, J:173534, J:181533)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Ift140 Mutation: |
71 strains or lines available
|
|
| Original: |
J:181533 Jonassen JA, et al., Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr;23(4):641-51 |
| All: |
6 reference(s) |
|
Analysis Tools
