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Allele Symbol Allele Name Allele ID |
Ift140tm1b(KOMP)Wtsi targeted mutation 1b, Wellcome Trust Sanger Institute MGI:5311831 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die at around E11.5
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• E10.5 embryos show expanded hindlimb field
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• E10.5 embryos exhibit an open mouth
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• E10.5 embryos exhibit an open mouth
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• E10.5 embryos show expanded hindlimb field
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• either very short or no cilia are present in collecting ducts at birth
• cilia continue to be present in decreasing numbers at 10 and 20 days of age
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• extensive cysts throughout the kidney by 20 days of age
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• present at 10 days of age
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• present at 5 and 10 days of age
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• only very short cilia are assembled
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• at birth
• stumpy cilia present at at 10 and 20 days of age
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• cystic kidneys are fibrotic
• increased interstitial cell smooth muscle actin
• increased collagen
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• at 20 days of age in non-collecting duct cells
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• percentage of mitotic cells is elevated and remains high in collecting ducts
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• during the third week of life
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| N |
• normal orientation of mitotic spindles in precystic collecting ducts of the kidney
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• either very short or no cilia are present in collecting ducts at birth
• cilia continue to be present in decreasing numbers at 10 and 20 days of age
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• at 20 days of age in non-collecting duct cells
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• percentage of mitotic cells is elevated and remains high in collecting ducts
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• extensive cysts throughout the kidney by 20 days of age
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• present at 10 days of age
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• present at 5 and 10 days of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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