Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Raxtm1.1Tfur
Name:	retina and anterior neural fold homeobox; targeted mutation 1.1, Takahisa Furukawa
MGI ID:	MGI:5302230
Synonyms:	Raxflox
Gene:	Rax  Location: Chr18:66067710-66072160 bp, - strand  Genetic Position: Chr18, 39.03 cM
Alliance:	Raxtm1.1Tfur page

Germline Transmission:	Earliest citation of germline transmission: J:177908
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was used to insert flox sites upstream of exon 1 and intron 2 by homologous recombination in ES cells. An Frt-flanked PGK-neo selection cassette was inserted also, and removed after selection of correctly targeted clones by Flp recombinase. Cre-mediated recombination will result in excision of exons 1 and 2 of Rax, producing a null allele. (J:177908)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rax Mutation:	16 strains or lines available

Original:	J:177908 Muranishi Y, et al., An Essential Role for RAX Homeoprotein and NOTCH-HES Signaling in Otx2 Expression in Embryonic Retinal Photoreceptor Cell Fate Determination. J Neurosci. 2011 Nov 16;31(46):16792-807
All:	4 reference(s)