Cdkal1tm1.1Tomik
Targeted Allele Detail
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Symbol: |
Cdkal1tm1.1Tomik |
Name: |
CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa |
MGI ID: |
MGI:5301441 |
Synonyms: |
Cdkal1flox |
Gene: |
Cdkal1 Location: Chr13:29375729-30039657 bp, - strand Genetic Position: Chr13, 12.93 cM, cytoband A3.3
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Alliance: |
Cdkal1tm1.1Tomik page
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Endoplasmic reticulum distention in Cdkal1tm1.2Tomik/Cdkal1tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:178248
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed.
(J:178248)
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Generation of the Cdkal1tm1.1Tomik and Cdkal1tm1.2Tomik alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cdkal1 Mutation: |
59 strains or lines available
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Original: |
J:178248 Wei FY, et al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608 |
All: |
1 reference(s) |
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