Tg(SIRPA)1Flv Transgene Detail MGI Mouse (MGI:5300383)

Tg(SIRPA)1Flv
Transgene Detail

Summary

Symbol:	Tg(SIRPA)1Flv
Name:	transgene insertion 1, Richard A Flavell
MGI ID:	MGI:5300383
Synonyms:	hSIRPa
Transgene:	Tg(SIRPA)1Flv Location: unknown
Alliance:	Tg(SIRPA)1Flv page

Transgene
origin

Germline Transmission:	Earliest citation of germline transmission: J:175623
Parent Cell Line:	V17 (ES Cell)
Strain of Origin:	BALB/cAnNTac x 129S4/SvJae

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(SIRPA)1Flv expresses 1 gene

Mutation details: The transgene contains a BAC encoding the entire 45 kb human SIRPA gene along with about 51 kb of 5' flanking DNA and 78 kb 3' flanking sequence. Line 1 was generated. (J:175623)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Previously targeted V17 ES cells carrying Rag2^tm1.1Flv and Il2rg^tm1.1Flv were used to generate the transgene.

References

Original:	J:175623 Strowig T, et al., Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13218-23
All:	13 reference(s)

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