Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ap2b1Tg(Tyr)427Ove
Name:	adaptor-related protein complex 2, beta 1 subunit; transgene insertion 427, Paul Overbeek
MGI ID:	MGI:5295975
Synonyms:	OVE427
Gene:	Ap2b1  Location: Chr11:83189850-83295861 bp, + strand  Genetic Position: Chr11, 50.3 cM, cytoband B5
Alliance:	Ap2b1Tg(Tyr)427Ove page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The 4.1 kb tyrosinase minigene (TYBS) transgene with the 2.1 kb BALB/c mouse Tyr promoter region and 2.0 kb Tyr cDNA sequence (including the stop codon polyA sequences) inserted into chromosome 11 in reverse-orientation with the left arm mapping to intron 1 and the right arm mapping to intron 14. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts, brain, and liver extracts. (J:177760)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ap2b1 Mutation:	72 strains or lines available

Original:	J:177760 Li W, et al., EDITOR'S CHOICE: Disruption of the Murine Ap2beta1 Gene Causes Nonsyndromic Cleft Palate. Cleft Palate Craniofac J. 2010 Nov;47(6):566-73
All:	1 reference(s)