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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ap2b1Tg(Tyr)427Ove
transgene insertion 427, Paul Overbeek
MGI:5295975
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ap2b1Tg(Tyr)427Ove/Ap2b1Tg(Tyr)427Ove FVB/NJ-Ap2b1Tg(Tyr)427Ove MGI:5295994


Genotype
MGI:5295994
hm1
Allelic
Composition		 Ap2b1Tg(Tyr)427Ove/Ap2b1Tg(Tyr)427Ove
Genetic
Background		 FVB/NJ-Ap2b1Tg(Tyr)427Ove
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2b1Tg(Tyr)427Ove mutation (1 available); any Ap2b1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal palatal shelf fusion at midline ( J:177760 )
• despite evidence of palatal shelf elevation, shelves fail to fuse at E17 and E18

digestive/alimentary system
abnormal palatal shelf fusion at midline ( J:177760 )
• despite evidence of palatal shelf elevation, shelves fail to fuse at E17 and E18

growth/size/body
abnormal palatal shelf fusion at midline ( J:177760 )
• despite evidence of palatal shelf elevation, shelves fail to fuse at E17 and E18
cleft palate ( J:177760 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory