Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Inca1tm1Cmt Name: inhibitor of CDK, cyclin A1 interacting protein 1; targeted mutation 1, Carsten Muller-Tidow MGI ID: MGI:5292392 Gene: Inca1  Location: Chr11:70579187-70590981 bp, - strand  Genetic Position: Chr11, 43.21 cM Alliance: Inca1tm1Cmt page

Disruption of splenic architecture in Inca1tm1Cmt/Inca1tm1Cmt mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:175667
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 through 7 were replaced with an IRES, lacZ, and floxed neo cassette. The absence of transcript expression was confirmed by RT-PCR on mouse embryonic fibroblasts, testis, liver, kidney, and lung extracts. (J:175667)

Generation of the Inca1tm1Cmt allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Inca1 Mutation:	15 strains or lines available

Original:	J:175667 Baumer N, et al., Inhibitor of Cyclin-dependent Kinase (CDK) Interacting with Cyclin A1 (INCA1) Regulates Proliferation and Is Repressed by Oncogenic Signaling. J Biol Chem. 2011 Aug 12;286(32):28210-22
All:	3 reference(s)