Phenotypes associated with this allele

• Allele Symbol: Inca1^tm1Cmt
• Allele Name: targeted mutation 1, Carsten Muller-Tidow
• Allele ID: MGI:5292392
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inca1^tm1Cmt/Inca1^tm1Cmt	involves: 129 * C57BL/6N	MGI:5292394

Genotype
MGI:5292394

hm1

• Allelic Composition: Inca1^tm1Cmt/Inca1^tm1Cmt
• Genetic Background: involves: 129 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Disruption of splenic architecture in Inca1^tm1Cmt/Inca1^tm1Cmt mice

hematopoietic system

extramedullary hematopoiesis ( J:175667 )

• in the spleen of mice older than 14 months

increased megakaryocyte cell number ( J:175667 )

• in mice older than 14 months

abnormal spleen morphology ( J:175667 )

• in mice older than 14 months

abnormal spleen white pulp morphology ( J:175667 )

• disorganized in mice older than 14 months

abnormal spleen B cell follicle morphology ( J:175667 )

• in mice older than 14 months

increased IgA level ( J:175667 )

• slightly slightly

immune system

abnormal spleen morphology ( J:175667 )

• in mice older than 14 months

abnormal spleen white pulp morphology ( J:175667 )

• disorganized in mice older than 14 months

abnormal spleen B cell follicle morphology ( J:175667 )

• in mice older than 14 months

increased IgA level ( J:175667 )

• slightly slightly

cellular

decreased fibroblast proliferation ( J:175667 )

• in mouse embryonic fibroblasts in mouse embryonic fibroblasts