Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Fbxw7tm1Itom
Name:	F-box and WD-40 domain protein 7; targeted mutation 1, Ian Tomlinson
MGI ID:	MGI:5007620
Synonyms:	Fbxw7flox, Fbxw7fl(R482Q)
Gene:	Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Alliance:	Fbxw7tm1Itom page

Germline Transmission:	Earliest citation of germline transmission: J:172214
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Single point mutation   Mutation details: A loxP site was inserted upstream of exon 9 and a floxed neo cassette and a 3.6 kb genomic fragment of Fbxw7 including a G to A mutation resulting in an arginine to glutamine substitution at position 482 was inserted after the polyA sequence. (J:172214)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Fbxw7tm1Itom

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:	82 strains or lines available

Original:	J:172214 Davis H, et al., FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol. 2011 Jun;224(2):180-9
All:	3 reference(s)