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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxw7tm1Itom
targeted mutation 1, Ian Tomlinson
MGI:5007620
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbxw7tm1Itom/Fbxw7+
Tg(Pgk1-cre)1Lni/0 		involves: 129 * BALB/c * C57BL/6 * C57BL/6J MGI:5007621


Genotype
MGI:5007621
cn1
Allelic
Composition		 Fbxw7tm1Itom/Fbxw7+
Tg(Pgk1-cre)1Lni/0
Genetic
Background		 involves: 129 * BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Itom mutation (0 available); any Fbxw7 mutation (82 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:172214 )
• all pups die shortly after birth

respiratory system
impaired lung alveolus development ( J:172214 )
• disruption of the canalicular and /or terminal sac stage of lung development
abnormal pulmonary alveolus wall morphology ( J:172214 )
• thickened alveolar septa at E18.5

vision/eye
eyelids open at birth ( J:172214 )
• in 17 of 40 mice

craniofacial
cleft palate ( J:172214 )
• in 30% of mice

digestive/alimentary system
cleft palate ( J:172214 )
• in 30% of mice

growth/size/body
cleft palate ( J:172214 )
• in 30% of mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory