Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crisp4tm1.2Mkob
Name:	cysteine-rich secretory protein 4; targeted mutation 1.2, Moira K O'Bryan
MGI ID:	MGI:4950060
Gene:	Crisp4  Location: Chr1:18185415-18216126 bp, - strand  Genetic Position: Chr1, 5.65 cM, cytoband A4
Alliance:	Crisp4tm1.2Mkob page

Germline Transmission:	Earliest citation of germline transmission: J:171346
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted into intron 2 and a floxed neo cassette was inserted into intro 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 3. Western blot and immunohistochemical analysis confirmed the absence of protein expression in epididymides from homozygous mice. (J:171346)

Generation of the Crisp4tm1.1Mkob and Crisp4tm1.2Mkob alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crisp4 Mutation:	21 strains or lines available

Original:	J:171346 Gibbs GM, et al., Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7034-9
All:	1 reference(s)