Tg(FCGRT)32Dcr
Transgene Detail
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| Symbol: |
Tg(FCGRT)32Dcr |
| Name: |
transgene insertion 32, Derry C Roopenian |
| MGI ID: |
MGI:4944199 |
| Synonyms: |
hFcRn(32) vhFcRn (32) Tg hFcRn (32) Tg, Tg32 |
| Transgene: |
Tg(FCGRT)32Dcr Location: Chr2:100912057-100912058 bp Genetic Position: Chr2, Syntenic
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| Alliance: |
Tg(FCGRT)32Dcr page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(FCGRT)32Dcr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FCGRT (2217) |
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Mutation details: A 34Kb fragment of a BAC containing the entire human FCGRT , Fc fragment of IgG, receptor, transporter, alpha, gene (approximately 11kb) and approximately 10kb of flanking sequence was sublconed into a SuperCos vector. The resulting cosmid was microinjected into fertilized C57BL/6J mouse eggs. Founder line 32 was established. Transgene insertion occurred on Chr 2.
(J:94189, J:133048)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 9 strains available
Cell Lines: 0 lines available
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| Original: |
J:133048 Petkova SB, et al., Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol. 2006 Dec;18(12):1759-69 |
| All: |
24 reference(s) |
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Analysis Tools
