Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Atmintm1.1Axbe Name: ATM interactor; targeted mutation 1.1, Axel Behrens MGI ID: MGI:4868762 Synonyms: ATMINdelta Gene: Atmin  Location: Chr8:117670132-117687184 bp, + strand  Genetic Position: Chr8, 63.37 cM Alliance: Atmintm1.1Axbe page

Midbrain exencephaly and accumulation of DNA damage in Atmintm1.1Axbe/Atmintm1.1Axbe embryos Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:167331
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exon 4. The absence of protein expression was confirmed by western blot analysis on whole embryo extracts. (J:167331)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atmin Mutation:	38 strains or lines available

Original:	J:167331 Kanu N, et al., The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010 Dec 3;285(49):38534-42
All:	2 reference(s)