Phenotypes associated with this allele

• Allele Symbol: Atmin^tm1.1Axbe
• Allele Name: targeted mutation 1.1, Axel Behrens
• Allele ID: MGI:4868762
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atmin^tm1.1Axbe/Atmin^tm1.1Axbe	involves: BALB/c * C57BL/6	MGI:4868764

Genotype
MGI:4868764

hm1

• Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Midbrain exencephaly and accumulation of DNA damage in Atmin^tm1.1Axbe/Atmin^tm1.1Axbe embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:167331 )

• around E16.5

cellular

abnormal cell physiology ( J:167331 )

• mouse embryonic fibroblasts exhibit increased DNA damage when cultured in high oxygen compared with wild-type mice

decreased cell proliferation ( J:167331 )

• of mouse embryonic fibroblasts after four passages in cultures at 3% and 20% oxygen

early cellular replicative senescence ( J:167331 )

• in mouse embryonic fibroblasts (MEFs)

• in MEFs in the presence of N-acetyl-L-cysteine

nervous system

exencephaly ( J:167331 )

• in the midbrain at E16.5

craniofacial

abnormal craniofacial morphology ( J:167331 )

• at E16.5