Gene Expression Data
Assay Details
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Assay
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Reference:
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J:61481
Chan JC, et al., Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice. J Clin Invest. 2000 Apr;105(7):897-903
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:4840018
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Gene symbol:
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Fgb
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Gene name:
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fibrinogen beta chain
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Antibody:
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anti-Fibrinogen
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Detection system:
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Secondary antibody coupled to horseradish peroxidase
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Assay notes:
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The authors did not specify which family member the antibody recognizes; all have been annotated. Sections were fixed in 1% paraformaldehyde.
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Results
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Specimen
1c:
(close  )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: liver |
Present |
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1c
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There is interstitial fibrin deposition.
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Specimen
1e:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: hindbrain |
Present |
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1e
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There is fibrin deposition.
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Specimen
1i:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
Not shown FVII+/+/PC-/-:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: brain |
Present |
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There is fibrin deposition in this mutant.
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| TS25: heart atrium |
Present |
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There is fibrin deposition in this mutant.
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| TS25: liver |
Present |
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There is fibrin deposition in this mutant.
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Specimen
Not shown FVII+/-/PC-/-:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7+
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: brain |
Present |
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There is fibrin deposition in this mutant.
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| TS25: heart atrium |
Present |
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There is fibrin deposition in this mutant.
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| TS25: liver |
Present |
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There is fibrin deposition in this mutant.
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Specimen
Not shown wild type:
embryonic day 17.5
(more  )
Specimen
Not shown wild type:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: brain |
Absent |
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There are no fibrin deposits in wild type embryos.
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| TS25: heart atrium |
Absent |
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There are no fibrin deposits in wild type embryos.
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| TS25: liver |
Absent |
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There are no fibrin deposits in wild type embryos.
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Specimen
Not shown FVII-/-/PC-+/+:
embryonic day 17.5; F7tm1Pec/ F7tm1Pec
(more )
Specimen
Not shown FVII-/-/PC-+/+:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: brain |
Absent |
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There are no fibrin deposits in this mutant embryo.
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| TS25: heart atrium |
Absent |
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There are no fibrin deposits in this mutant embryo.
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| TS25: liver |
Absent |
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There are no fibrin deposits in this mutant embryo.
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Specimen
2c:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: head |
Present |
Regionally restricted |
2c
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Fibrin deposits are in the snout.
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Specimen
Not shown FVII+/-/PC-/-:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7+
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: liver |
Present |
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There is fibrin deposition in this mutant.
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| TS22: brain |
Present |
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Fibron deposition in the brain is less than in the liver.
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Specimen
3a:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
3b:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: liver |
Present |
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3b
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There is interstitial fibrin deposition in this mutant embryo.
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Specimen
Not shown:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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Mutant Allele(s):
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F7tm1Pec/F7tm1Pec
Proctm1Fjc/Proctm1Fjc
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Paraformaldehyde
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Embedding:
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Paraffin
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Analysis Tools