Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cxcr4tm1Yiw
Name:	C-X-C motif chemokine receptor 4; targeted mutation 1, Yoichiro Iwakura
MGI ID:	MGI:4836915
Synonyms:	Cxcr4flox
Gene:	Cxcr4  Location: Chr1:128515936-128520030 bp, - strand  Genetic Position: Chr1, 56.43 cM
Alliance:	Cxcr4tm1Yiw page

Germline Transmission:	Earliest citation of germline transmission: J:164872
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 2 was floxed and a neomycin resistant cassette was inserted 5' to the second loxP site within intron 2. (J:164872)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:	40 strains or lines available

Original:	J:164872 Chung SH, et al., CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther. 2010 Oct 12;12(5):R188
All:	5 reference(s)