Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plautm1.1Bug
Name:	plasminogen activator, urokinase; targeted mutation 1.1, Thomas H Bugge
MGI ID:	MGI:4836576
Synonyms:	PlauGFDhu, uPAY23N-R28N-R30H-R31W
Gene:	Plau  Location: Chr14:20886728-20893453 bp, + strand  Genetic Position: Chr14, 11.53 cM
Alliance:	Plautm1.1Bug page

Germline Transmission:	Earliest citation of germline transmission: J:164542
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 4 was replaced with one in which nucleotide substitutions (resulting in the amino acid substitutions Y23N, R28N, R30H, and R31W) abolish the ligand receptor interacting domain governed by the burial of the beta-hairpin of the growth factor domain (GFD). The overal structure and catalytic function of the protein is preserved. A floxed neo cassette inserted downstream of the modified exon 4 was removed by cre mediated recombination. (J:164542)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plau Mutation:	27 strains or lines available

Original:	J:164542 Connolly BM, et al., Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 2010 Sep 2;116(9):1593-603
All:	7 reference(s)