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Tg(Myh6-Agt)153Tped
Transgene Detail
Summary
Symbol: Tg(Myh6-Agt)153Tped
Name: transgene insertion 153, Thierry Pedrazzini
MGI ID: MGI:3795514
Synonyms: TG153
Transgene: Tg(Myh6-Agt)153Tped  Location: unknown  
Alliance: Tg(Myh6-Agt)153Tped page
Transgene
origin
Strain of Origin:  C57BL/6 x BALB/c
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Agt)153Tped expresses 1 gene
 
Mutation details: The transgene is composed of a 1.9-kb rat AGT cDNA coupled to a 5.8-kb mouse alpha-MHC gene promoter. 1.6 kb of the rabbit bIVS2 intronic sequences are also included. RT-PCR analysis indeicated that this transgene was expressed specifically in the heart. Five copies of the transgene are integrated in TG153 transgenic mice. (J:129140)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
The transgene construct was injected into either NMRI (two-renin gene strain) or C57BL/6 x BALB/c (one-renin gene strains) mice. A third line was created by crossing transgenic NMRI mice with C57BL/6 animals to generate one-renin gene mice carrying the same transgene number as transgenic NMRI. (J:129140)
References
Original:  J:129140 Mazzolai L, et al., Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension. 1998 Jun;31(6):1324-30
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory