Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Dp(10Prmt2-Pdxk)2Yey
Name:	duplication, Chr 10, Y Eugene Yu 2
MGI ID:	MGI:4461400
Synonyms:	Dp(10)1Yey, Dp(10Prmt2-Pdxk)1Yey, Dp2Yey, Ts2Yey
Gene:	Dp(10Prmt2-Pdxk)2Yey  Location: Chr10:76043060-78300782 bp  Genetic Position: Chr10, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:161325
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Not Applicable) Mutation:    Duplication   Dp(10Prmt2-Pdxk)2Yey involves 85 genes/genome features (Gm19376, n-R5s77, n-TAagc5 ...) View all   Mutation details: Cre mediated chromosomal rearrangement between loxP sites in regions proximal to Prmt2 and distal to Pdxk results in duplication of the genes, including Prmt2 and Pdxk, in this approximately 2.3 Mb region that is syntenic with the distal part of human 21q22.3. (J:161325)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Dp(10Prmt2-Pdxk)2Yey Mutation:	3 strains or lines available

Original:	J:161325 Yu T, et al., A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010 Jul 15;19(14):2780-91
All:	18 reference(s)