Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mir140tm1.1Asah
Name:	microRNA 140; targeted mutation 1.1, Hiroshi Asahara
MGI ID:	MGI:4461000
Synonyms:	pre-miR-140-null
Gene:	Mir140  Location: Chr8:108277876-108277945 bp, + strand  Genetic Position: Chr8, 54.33 cM
Alliance:	Mir140tm1.1Asah page

Germline Transmission:	Earliest citation of germline transmission: J:160358
Parent Cell Line:	TT2F (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire pre-microRNA sequence was replaced with a floxed neo cassette. Cre mediated recombination removed the neo cassette. QPCR confirmed the absence of transcript expression in E11.5 embryo extracts. (J:160358)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir140 Mutation:	1 strain or line available

Original:	J:160358 Miyaki S, et al., MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010 Jun 1;24(11):1173-85
All:	4 reference(s)