Phenotypes associated with this allele

• Allele Symbol: Mir140^tm1.1Asah
• Allele Name: targeted mutation 1.1, Hiroshi Asahara
• Allele ID: MGI:4461000
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir140^tm1.1Asah/Mir140^tm1.1Asah	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:4461004

Genotype
MGI:4461004

hm1

• Allelic Composition: Mir140^tm1.1Asah/Mir140^tm1.1Asah
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:160358 )

N

abnormal skeleton morphology ( J:160358 )

short maxilla ( J:160358 )

short nasal bone ( J:160358 )

domed cranium ( J:160358 )

decreased long bone epiphyseal plate size ( J:160358 )

decreased length of long bones ( J:160358 )

abnormal skeleton physiology ( J:160358 )

increased susceptibility to induced arthritis ( J:160358 )

• antigen-induced

osteoarthritis ( J:160358 )

• mice exhibit age-related osteoarthritis in articular cartilage unlike wild-type mice

abnormal chondrocyte physiology ( J:160358 )

• at P10, chondrocyte proliferation is decreased compared with wild-type cells

growth/size/body

short maxilla ( J:160358 )

short nasal bone ( J:160358 )

short snout ( J:160358 )

decreased body weight ( J:160358 )

decreased body height ( J:160358 )

postnatal growth retardation ( J:160358 )

• 1 week after birth

craniofacial

short maxilla ( J:160358 )

short nasal bone ( J:160358 )

domed cranium ( J:160358 )

short snout ( J:160358 )

immune system

increased susceptibility to induced arthritis ( J:160358 )

• antigen-induced

osteoarthritis ( J:160358 )

• mice exhibit age-related osteoarthritis in articular cartilage unlike wild-type mice

respiratory system

short nasal bone ( J:160358 )