Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(LRRK2*G2019S)1Mjfa
Name:	transgene insertion 1, Matthew Farrer
MGI ID:	MGI:4460658
Synonyms:	LRRK2 GS G2019S
Transgene:	Tg(LRRK2*G2019S)1Mjfa  Location: unknown  Genetic Position: Chr13, Syntenic
Alliance:	Tg(LRRK2*G2019S)1Mjfa page

Strain of Origin:

FVB/NTac

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(LRRK2*G2019S)1Mjfa expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human LRRK2 (120892) Lrrk2  (MGI:1913975)   Mutation details: These transgenic mice express the mutant human LRRK2 sequence, 6055G->A transition (G2019S), with high levels of protein detected in an expression pattern similar to that of the endogenous mouse Lrrk2. The transgene inserted into Chromosome 13. Transgenic mice express mutant human LRRK2 at approximately 8-10 fold over the endogenous mouse Lrrk2 level. Line 1 was generated. (J:161657)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:161657 Farrer MJ, et al., LRRK2 GS G2019S transgenic strain. MGI Direct Data Submission. 2010;
All:	6 reference(s)