Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dgcr8tm1.1Blel
Name:	DGCR8, microprocessor complex subunit; targeted mutation 1.1, Robert Blelloch
MGI ID:	MGI:4458072
Synonyms:	Dgcr2lox
Gene:	Dgcr8  Location: Chr16:18071812-18107110 bp, - strand  Genetic Position: Chr16, 11.31 cM, cytoband B1
Alliance:	Dgcr8tm1.1Blel page

Germline Transmission:	Earliest citation of germline transmission: J:161342
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted in intron 2 and a floxed CMV-Hygro selection cassette was inserted in intron 3. ES cells were sequentially targeted so that ES cells carried two mutated alleles. Cre recombinase treatment of these ES cells resulted in two mutant alleles, this one with a floxed exon 3 but lacking the selection cassette and another allele which lacks both exon 3 and the selection cassette. (J:141670)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dgcr8 Mutation:	67 strains or lines available

Original:	J:161342 Rao PK, et al., Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res. 2009 Sep 11;105(6):585-94
All:	47 reference(s)