Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gdnftm1.1Neas
Name:	glial cell line derived neurotrophic factor; targeted mutation 1.1, Neil A Shneider
MGI ID:	MGI:4456155
Synonyms:	GDNFFLOX
Gene:	Gdnf  Location: Chr15:7840327-7867056 bp, + strand  Genetic Position: Chr15, 3.8 cM
Alliance:	Gdnftm1.1Neas page

Germline Transmission:	Earliest citation of germline transmission: J:160727
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt flanked neo cassette was inserted upstream of a modified exon 3 in which the coding sequence was floxed. Flp mediated recombination removed the neo cassette leaving the coding sequence floxed. (J:160727)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gdnf Mutation:	18 strains or lines available

Original:	J:160727 Shneider NA, et al., Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. Neural Dev. 2009;4:42
All:	4 reference(s)