Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Gh1-cre)bKnmn
Name:	transgene insertion b, Rhonda D Kineman
MGI ID:	MGI:4442901
Synonyms:	rGHp-Cre
Transgene:	Tg(Gh1-cre)bKnmn  Location: unknown
Alliance:	Tg(Gh1-cre)bKnmn page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Gh1-cre)bKnmn expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Gh1 (24391) Gh  (MGI:95707)   Mutation details: A 310 bp fragment 5' of the initiation codon of the rat growth hormone gene (Gh1) was used to drive cre recombinase in the construct. The purified construct was injected into FVB zygotes. Line b was determined (by Southern blot) to carry 3 copies of the insertion was established and analyzed in detail. RT-PCR results demonstrated high levels of cre mRNA expression in the pituitary, lower levels in the testis, and no expression in any other tissues. (Cre expression was also detected in cephalic extracts from animals at E17.) (J:122251)

Activity:	Tissue activity of this recombinase allele
Driver:	Gh1 (rat) Summary of all recombinase alleles driven by Gh1. Comparative matrix view of recombinase activities Alliance rat Gh1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:122251 Luque RM, et al., Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland. Endocrinology. 2007 May;148(5):1946-53
All:	21 reference(s)