Tg(CAG-FCGRT)276Dcr
Transgene Detail
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| Symbol: |
Tg(CAG-FCGRT)276Dcr |
| Name: |
transgene insertion 276, Derry C Roopenian |
| MGI ID: |
MGI:4441040 |
| Synonyms: |
hFcRn (276) Tg, Tg276 |
| Transgene: |
Tg(CAG-FCGRT)276Dcr Location: Chr1:184861574-184861575 bp Genetic Position: Chr1, Syntenic
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| Alliance: |
Tg(CAG-FCGRT)276Dcr page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutations: |
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Duplication, Insertion
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Tg(CAG-FCGRT)276Dcr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FCGRT (2217) |
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Mutation details: To generate the hFcRn line 276 transgenic mice, a transgene was designed with the 0.34 kb human cytomegalovirus immediate early promoter enhancer, 1.4 kb chicken beta-actin promoter and intron 1, a cDNA sequence encoding the human FcRn alpha-chain, 0.73 kb rabbit beta-globin intron, and 0.35 kb SV40 polyA sequence. Line 276 was established. Transgene insertion occurred on Chr 1, causing a 1 bp duplication.
(J:110885)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 3 strains available
Cell Lines: 0 lines available
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| Original: |
J:110885 Chaudhury C, et al., The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med. 2003 Feb 3;197(3):315-22 |
| All: |
18 reference(s) |
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Analysis Tools
