Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Dnajc6tm1Legr Name: DnaJ heat shock protein family (Hsp40) member C6; targeted mutation 1, Lois Greene MGI ID: MGI:4440489 Synonyms: Dnajc6tm1Pdc Gene: Dnajc6  Location: Chr4:101353828-101499996 bp, + strand  Genetic Position: Chr4, 46.89 cM Alliance: Dnajc6tm1Legr page

Accumulation of clathrin-coated vesicles and clathrin cages at Dnajc6tm1Legr/Dnajc6tm1Legr synapses from deep cerebellar nuclei Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:158574
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:158574)

Generation of the Dnajc6tm1Legr allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnajc6 Mutation:	59 strains or lines available

Original:	J:158574 Yim YI, et al., Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4412-7
All:	3 reference(s)