Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pvalbtm1.1(cre)Aibs
Name:	parvalbumin; targeted mutation 1.1, Allen Institute for Brain Science
MGI ID:	MGI:4421793
Synonyms:	Pvalb-2A-Cre, Pvalbtm1(cre)Aibs, PvCre(Aibs)
Gene:	Pvalb  Location: Chr15:78075314-78090600 bp, - strand  Genetic Position: Chr15, 36.93 cM, cytoband E
Alliance:	Pvalbtm1.1(cre)Aibs page

Germline Transmission:	Earliest citation of germline transmission: J:155793
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Pvalbtm1.1(cre)Aibs expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pvalb (MGI:97821)   Mutation details: A targeting vector was designed to insert a viral 2A oligopeptide that mediates ribosomal skipping and a Cre recombinase gene immediately downstream of the parvalbumin translational STOP codon. The targeting vector contained, from 5' to 3', a 3 amino acid linker sequence, an frt3 site, a viral 2A oligopeptide, a Cre recombinase gene, a translational STOP sequence (TAA codon), an attB site, a PGK-Neo-polyA cassette, an frt5 site, an RNA splice acceptor, the 3' portion of the hygromycin gene with SV40 polyA signal, and attP site. This construct was electroporated into (129S6/SvEvTac x C57BL/6)F1-derived G4 embryonic stem (ES) cells. (J:155793)

Activity:	Tissue activity of this recombinase allele
Driver:	Pvalb (mouse) Summary of all recombinase alleles driven by Pvalb. Comparative matrix view of recombinase activities Alliance mouse Pvalb gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pvalb Mutation:	29 strains or lines available

Original:	J:155793 Madisen L, et al., A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010 Jan;13(1):133-40
All:	34 reference(s)