Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abl1tm1Goff
Name:	c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Stephen P Goff
MGI ID:	MGI:4421531
Synonyms:	Abl1m3
Gene:	Abl1  Location: Chr2:31578388-31694239 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Alliance:	Abl1tm1Goff page

Germline Transmission:	Earliest citation of germline transmission: J:156743
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A mutated NLS1with 5 amino acid substitutions (Lys to Gly) was introduced into exon 11 and a floxed neo cassette was introduced into intron 10 via homologous recombination. Western blot analysis revealed barely detectable levels of the full length mutant protein and low levels of a fragment consisting of the N terminal half. (J:156743)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:	92 strains or lines available

Original:	J:156743 Qiu Z, et al., c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1136-41
All:	1 reference(s)