Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Goff mutation
(1 available);
any
Abl1 mutation
(92 available)
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mortality/aging
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• high levels of perinatal lethality
• mice are stated to be phenotypically indistinguishable from Abl1 null mice
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cardiovascular system
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• decrease in the size of the ventricular lumens
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Goff mutation
(1 available);
any
Abl1 mutation
(92 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
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mortality/aging
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• most die shortly after birth
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cardiovascular system
N |
• compared to homozygous mutant mice not carrying the cre transgene, cardiomyocyte overproliferation and ventricular lumen size reduction are dramatically reduced
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• not as thick as in homozygous mutant mice not carrying the cre transgene but slightly thicker than in heterozygous controls
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