Cd79atm2(cre/Esr1*)Reth
Targeted Allele Detail
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Symbol: |
Cd79atm2(cre/Esr1*)Reth |
Name: |
CD79A antigen (immunoglobulin-associated alpha); targeted mutation 2, Michael Reth |
MGI ID: |
MGI:4414764 |
Synonyms: |
mb1-MerCreMEr |
Gene: |
Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
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Alliance: |
Cd79atm2(cre/Esr1*)Reth page
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Germline Transmission: |
Earliest citation of germline transmission:
J:155473
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Cd79atm2(cre/Esr1*)Reth expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cd79a (MGI:101774) |
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Mutation details: The MerCreMer construct, which contains two mutated mouse estrogen receptors flanking the cre coding region, was knocked into the locus. This construct sequesters the cre fusion in the cytoplasm until estrogen or a derivative is administered.
(J:155473)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cd79a
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd79a Mutation: |
22 strains or lines available
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Original: |
J:155473 Duber S, et al., Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood. 2009 Dec 3;114(24):4960-7 |
All: |
2 reference(s) |
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