Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Efemp2tm1.1Tynk
Name:	epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 1.1, Tomoyuki Nakamura
MGI ID:	MGI:4410301
Synonyms:	Fbln4flox
Gene:	Efemp2  Location: Chr19:5523982-5532545 bp, + strand  Genetic Position: Chr19, 4.33 cM, cytoband A
Alliance:	Efemp2tm1.1Tynk page

Germline Transmission:	Earliest citation of germline transmission: J:154659
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon2 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination removes the neo cassette leaving exon 2 floxed. (J:154659)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Efemp2 Mutation:	26 strains or lines available

Original:	J:154659 Horiguchi M, et al., Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19029-34
All:	1 reference(s)