Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ankle1tm1(KOMP)Wtsi
Name:	ankyrin repeat and LEM domain containing 1; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID:	MGI:4363814
Synonyms:	Ankle1-
Gene:	Ankle1  Location: Chr8:71858654-71862548 bp, + strand  Genetic Position: Chr8, 34.43 cM
Alliance:	Ankle1tm1(KOMP)Wtsi page
IMPC:	Ankle1 gene page

Mutant Cell Lines:	EPD0323_2_A11, EPD0323_2_B10, EPD0323_2_B12, EPD0323_2_C10, EPD0323_2_E10, EPD0323_2_E11, EPD0323_2_F09, EPD0323_2_F11, EPD0323_2_G09, EPD0323_2_H10
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3233 starting at position 71858819 and ending at position 71862052 of Chromosome 8 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Generation of the Ankle1tm1(KOMP)Wtsi, Ankle1tm1.1(KOMP)Wtsi and Ankle1tm1.2(KOMP)Wtsi alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Ankle1 Mutation:	27 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	5 reference(s)