Grik4tm1(cre)Ksak
Targeted Allele Detail
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Symbol: |
Grik4tm1(cre)Ksak |
Name: |
glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Kenji Sakimura |
MGI ID: |
MGI:4360478 |
Synonyms: |
Grik4-Cre, telencephalin-Cre |
Gene: |
Grik4 Location: Chr9:42431708-42856296 bp, - strand Genetic Position: Chr9, 23.8 cM
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Alliance: |
Grik4tm1(cre)Ksak page
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Germline Transmission: |
Earliest citation of germline transmission:
J:152455
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Grik4tm1(cre)Ksak expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Grik4 (MGI:95817) |
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Mutation details: Cre was inserted 3' to the translational start site and replaced the remainder of the first coding exon. Cre-driven expression is primarily in CA3 pyramidal cells of the hippocampus.
(J:152455)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Grik4
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grik4 Mutation: |
48 strains or lines available
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Original: |
J:152455 Akashi K, et al., NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009 Sep 2;29(35):10869-82 |
All: |
5 reference(s) |
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