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Grik4tm1(cre)Ksak
Targeted Allele Detail
Summary
Symbol: Grik4tm1(cre)Ksak
Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Kenji Sakimura
MGI ID: MGI:4360478
Synonyms: Grik4-Cre, telencephalin-Cre
Gene: Grik4  Location: Chr9:42431708-42856296 bp, - strand  Genetic Position: Chr9, 23.8 cM
Alliance: Grik4tm1(cre)Ksak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152455
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Grik4tm1(cre)Ksak expression driven by 1 gene
 
Mutation detailsCre was inserted 3' to the translational start site and replaced the remainder of the first coding exon. Cre-driven expression is primarily in CA3 pyramidal cells of the hippocampus. (J:152455)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Grik4 (mouse)
Summary of all recombinase alleles driven by Grik4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik4 Mutation:  48 strains or lines available
References
Original:  J:152455 Akashi K, et al., NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009 Sep 2;29(35):10869-82
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory