Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nanos3tm2.1(cre)Ysa
Name:	nanos C2HC-type zinc finger 3; targeted mutation 2.1, Yumiko Saga
MGI ID:	MGI:4358405
Synonyms:	Nanos3Cre
Gene:	Nanos3  Location: Chr8:84900359-84911396 bp, - strand  Genetic Position: Chr8, 40.45 cM
Alliance:	Nanos3tm2.1(cre)Ysa page

Germline Transmission:	Earliest citation of germline transmission: J:136687
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Nanos3tm2.1(cre)Ysa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Nanos3 (MGI:2675387)   Mutation details: The coding sequence for Cre recombinase, followed by the SV40 polyadenylation signal and a single frt site, resides in the first coding intron of the endogenous gene immediately following the ATG translation initiation codon. (J:136687)

Activity:	Tissue activity of this recombinase allele
Driver:	Nanos3 (mouse) Summary of all recombinase alleles driven by Nanos3. Alliance mouse Nanos3 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nanos3 Mutation:	28 strains or lines available

Original:	J:136687 Suzuki H, et al., Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol. 2008 Jun 1;318(1):133-42
All:	10 reference(s)