Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Snord116tm1Jbro
Name:	small nucleolar RNA, C/D box 116 cluster; targeted mutation 1, Jurgen Brosius
MGI ID:	MGI:4356428
Synonyms:	PWScr5'LoxP
Gene:	Snord116  Location: unknown  Genetic Position: Chr7, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:152022
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (No functional change, Not Applicable) Mutation:    Insertion   Mutation details: A cassette containing the 5' half of the HPRT mini-gene (driven by the Pgk promoter), a loxP site and a neomycin resistance gene (driven by the Polr2a promoter), was inserted 5' of Snord116. Mice with this allele don't display a discernible phenotype. When expressed from the maternal allele, this construct forces the expression of the snoRNA genes in the, normally maternally imprinted, Snord116 and Snord115 clusters. (J:152022)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snord116 Mutation:	3 strains or lines available

Original:	J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
All:	3 reference(s)