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Snord116 Complex/Cluster/Region Detail
Summary
  • Symbol
    Snord116
  • Name
    small nucleolar RNA, C/D box 116 cluster
  • Synonyms
    MBII-85, Pwcr1
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    3 experiments
Human Diseases
more
  • Diseases
    1 with Snord116 mouse models

Human Disease Mouse Models
       Prader-Willi Syndrome; PWS   OMIM: 176270 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Snord116
The Snord116 gene cluster is imprinted and only expressed from the paternal allele. Deletions of the Snord116 cluster may be useful in studying the role of Snord116 in growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome (PWS).
Gene Ontology
(GO)
Classifications
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Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic AC026683 GenBank | EMBL | DDBJ | MGI Sequence Detail 179493 C57BL/6J ±  kb
transcript AF241256 GenBank | EMBL | DDBJ | MGI Sequence Detail 2518 Not Specified  
For the selected sequence
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 3
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 21
    Developmental Gene Expression 8
    Diseases 2
    Phenotypes 7
  • Earliest
    J:65556 de Los Santos T, et al., Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the prader-willi deletion region, which Is highly expressed in brain. Am J Hum Genet. 2000 Nov;67(5):1067-82
  • Latest
    J:217174 Nakagaki A, et al., Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014 Dec 10;553(1):63-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory