Snord116
Complex/Cluster/Region Detail

Symbol Name ID

Snord116 small nucleolar RNA, C/D box 116 cluster MGI:1891407

Synonyms

MBII-85, Pwcr1

Feature Type

complex/cluster/region

Genetic Map

Chromosome 7
Syntenic

Mapping data(3)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

The Snord116 gene cluster is imprinted and only expressed from the paternal allele. Deletions of the Snord116 cluster may be useful in studying the role of Snord116 in growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome (PWS).

 
Human Diseases Modeled Using Mouse Snord116 (1)    Alleles Annotated to Human Diseases(2)   

Expression

Literature Summary: (7 records)
Data Summary: Results (22)    Tissues (13)    Images (1)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	18
RT-PCR	4

Molecular reagents

All nucleic(8) Genomic(1) cDNA(3) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

UniGene	423722
NIA Mouse Gene Index	U303623, U350186, U354712, U356230, U356770, U358554, U359202, U359783

Sequences

Length	Strain/Species
genomic	AC026683	GenBank | EMBL | DDBJ | MGI Sequence Detail	179493	C57BL/6J
transcript	AF241256	GenBank | EMBL | DDBJ | MGI Sequence Detail	2518	Not Specified

All sequences(11)

References

(Earliest) J:65556 de Los Santos T, et al., Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the prader-willi deletion region, which Is highly expressed in brain. Am J Hum Genet. 2000 Nov;67(5):1067-82
(Latest) J:172308 Stefan M, et al., Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab. 2011 May;300(5):E909-22
All references(16)