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Snord116 Complex/Cluster/Region Detail
Summary
  • Symbol
    Snord116
  • Name
    small nucleolar RNA, C/D box 116 cluster
  • Synonyms
    MBII-85, Pwcr1
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    3 experiments
Human Diseases
more
  • Diseases
    1 with Snord116 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The Snord116 gene cluster is imprinted and only expressed from the paternal allele. Deletions of the Snord116 cluster may be useful in studying the role of Snord116 in growth and feeding regulation, mechanisms of obesity, and pathophysiology of Prader-Willi syndrome (PWS).
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic AC026683 GenBank | EMBL | DDBJ | MGI Sequence Detail 179493 C57BL/6J ±  kb
    transcript AF241256 GenBank | EMBL | DDBJ | MGI Sequence Detail 2518 Not Specified  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 3
      Primer pair 3
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 8
      Diseases 1
      Phenotypes 11
    • Earliest
      J:65556 de Los Santos T, et al., Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the prader-willi deletion region, which Is highly expressed in brain. Am J Hum Genet. 2000 Nov;67(5):1067-82
    • Latest
      J:260797 Polex-Wolf J, et al., Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome. J Clin Invest. 2018 Mar 1;128(3):960-969

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory