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Gene Expression Data
Assay Details
Assay
Reference: J:76619 Barlow GM, et al., Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?. Biochem Biophys Res Commun. 2002 May 10;293(3):881-91
Assay type: RNA in situ
MGI Accession ID: MGI:4356119
Gene symbol: Dscam
Gene name: DS cell adhesion molecule
Probe: CHD2M-14
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 2Aa: embryonic day 12.5 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS20: spinal cord Present Graded 2Aa Ventral expression predominates.

Specimen 2Bf: embryonic day 12.5 (more )
Note: This is a transverse section at the level of the heart and forelimbs.
Structure Level Pattern Image Note
TS20: spinal cord Present Graded 2Bf Ventral expression predominates along the rostro-caudal axis of the spinal cord.

Specimen 2Bk: embryonic day 12.5 (more )
Note: This is a transverse section at the level of the liver and hindlimbs.
Structure Level Pattern Image Note
TS20: spinal cord Present Graded 2Bk Ventral expression predominates along the rostro-caudal axis of the spinal cord.

Specimen 3a: embryonic day 10.5 (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 3a Expression is present in the ventral neural tube, where it is seen in the motor neuroblasts.

Specimen 3c: embryonic day 11.5 (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS19: future spinal cord Strong Regionally restricted 3c Expression is present in the developing motor neurons of the ventral neural tube.

Specimen 3e: embryonic day 12.5 (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS20: spinal cord Present Graded 3e Expression in the motor cells of the ventral spinal cord predominates.

Specimen Not shown: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: spinal cord Present Graded Expression in the motor cells of the ventral spinal cord predominates.

Specimen 3g: embryonic day 18.5 (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS26: spinal cord Present Uniform 3g Expression is present throughout the spinal cord, with no distinct ventral/dorsal gradient.

Specimen 3i: postnatal adult (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS28: spinal cord Strong Non-Uniform 3i Expression is somewhat stronger in the ventral regions.

Specimen Not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted Expression is present in the preplate plexus, particularly in the Cajal-Retzius cells.
TS19: telencephalon ventricular layer Present

Specimen 4a: embryonic day 12.5 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS20: cerebral cortex Present Regionally restricted 4a Expression is present in the outermost layer of the neocortex. There is strong expression in the region of the future septum pellucidum.
TS20: ganglionic eminence Present Non-Uniform 4a Expression is stronger ventrally.
TS20: thalamus Present 4a Expression is present in the thalamus and the subthalamic nuclei.
TS20: midbrain Present 4a
TS20: medulla oblongata Present Non-Uniform 4a
TS20: metencephalon Present Non-Uniform 4a
TS20: cerebellum primordium Present 4a Expression is present in the rhombic lip of His.

Specimen 4c: embryonic day 14.5 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS22: cerebral cortex Present Regionally restricted 4c Expression is present in a single broad band.
TS22: ganglionic eminence Present 4c
TS22: medulla oblongata Present 4c
TS22: midbrain Present 4c
TS22: tectum Present 4c

Specimen 4e: postnatal day 1 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS27: neocortex layer Present Non-Uniform 4e Expression is present in all cortical layers but is more strongly expressed in the midlayers.
TS27: cingulate cortex Present Regionally restricted 4e Expression is present in the retrosplenial granular cortex.

Specimen 4g: postnatal day 1 (more )
Note: This is a coronal section.
Structure Level Pattern Image Note
TS27: neocortex layer Present Non-Uniform 4g Expression is present in all cortical layers but is more strongly expressed in the midlayers.
TS27: cingulate cortex Present Regionally restricted 4g Expression is present in the retrosplenial granular cortex.

Specimen 5a: postnatal month 6 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS28: cortical layer III Present 5c , 5a The strongest cortical expression level is found in the pyramidal neurons of layers 3 and 5.
TS28: cortical layer V Present 5c , 5a The strongest cortical expression level is found in the pyramidal neurons of layers 3 and 5.
TS28: hippocampus Present Non-Uniform 5a , 5c
TS28: dentate gyrus granule cell layer Present 5c , 5a This is one of the regions of strongest expression in the hippocampus.
TS28: hippocampus pyramidal cell layer Present 5c , 5a This is one of the regions of strongest expression in the hippocampus.

Specimen 5e: postnatal day 7 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS28: main olfactory bulb Strong Regionally restricted 5e There is strong expression in the neuronal layers.

Specimen 6a: postnatal newborn (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS27: cerebellum Present 6a Structural definition is not yet distinct.

Specimen 6c: postnatal adult (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 6e , 6c
TS28: deep cerebellar nucleus Strong 6e , 6c
TS28: cerebellum granule cell layer Present 6e , 6c


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory