Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Ckm-Ppargc1b)T37Brsp
Name:	transgene insertion T37, Bruce M Spiegelman
MGI ID:	MGI:4354127
Synonyms:	MCK-PGC-1b, PGC-1b
Transgene:	Tg(Ckm-Ppargc1b)T37Brsp  Location: unknown
Alliance:	Tg(Ckm-Ppargc1b)T37Brsp page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Ckm-Ppargc1b)T37Brsp expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Ppargc1b (MGI:2444934)   Mutation details: A transgenic construct containing the complete mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta gene cDNA, the 4.8kb mouse muscle creatine kinase promoter and the human growth hormone polyadenylation site was injected into fertilized FVB mouse eggs. Three lines were generated. Founder line T37 was subsequently established. Expression of Ppargc1b mRNA is increased 10-fold in the quadriceps, and transgene expression is higher in 'white', glycolytic muscle (EDL, quadriceps, gastrocnemius) than in 'red', oxidative muscle (soleus, heart). (J:118258)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:118258 Arany Z, et al., The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007 Jan;5(1):35-46
All:	4 reference(s)