Phenotypes associated with this allele

• Allele Symbol: Tg(Ckm-Ppargc1b)T37Brsp
• Allele Name: transgene insertion T37, Bruce M Spiegelman
• Allele ID: MGI:4354127
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ckm-Ppargc1b)T37Brsp/0	FVB-Tg(Ckm-Ppargc1b)T37Brsp	MGI:4354145

Genotype
MGI:4354145

tg1

• Allelic Composition: Tg(Ckm-Ppargc1b)T37Brsp/0
• Genetic Background: FVB-Tg(Ckm-Ppargc1b)T37Brsp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:118258 )

• muscle is strikingly redder than in non-transgenic littermates

decreased skeletal muscle fiber size ( J:118258 )

• fibers are smaller than in wild-type controls

abnormal skeletal muscle fiber type ratio ( J:118258 )

• muscles contain predominantly oxidative fibers in contrast to normal muscles which contain mix of glycolytic and oxidative fibers; tibialis anterior muscle in wild-type contains mostly glycolytic fibers, whereas in transgenic animals, every fiber is oxidative

• fibers with type IIX (fast-twitch, oxidative) characteristics are strongly induced in transgenic muscles

skeletal muscle hypoplasia ( J:118258 )

• muscles in mutants are slightly smaller than in controls, due to decreased fiber size

abnormal muscle physiology ( J:118258 )

homeostasis/metabolism

enhanced exercise endurance ( J:118258 )

• transgenic animals have an increased capacity for oxidative work (such as exercise); in a treadmill running paradigm, wild-type animals run for 26.5 min to exhaustion, in contrast to transgenic littermates which can run 32.5 min until reaching exhaustion

cellular

abnormal mitochondrial morphology ( J:118258 )

• induction of mitochondria is increased in transgenic muscle compared to wild-type