Summary | Transgene origin | Transgene description | Recombinase activity | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde
Name:	transgene insertion 14, Benoit Van den Eynde
MGI ID:	MGI:4354014
Synonyms:	Tg(Tyr-cre/ESR1*,-Hras1*,-Trap1a)14Jvde, TiRP-14
Transgene:	Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde  Location: unknown
Alliance:	Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Conditional ready, Inducible, Inserted expressed sequence, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Tyr (MGI:98880)   Mutation details: The mouse promoter was used to drive tamoxifen-inducible, melanocyte-specific expression of a floxed cre/ESR1 fusion containing the aminoacid substitution G521R followed out of frame by a constitutively active Hras1 with the G12V amino acid substitution, an IRES, and the mouse cDNA for Trap1a with its polyadenylation signal. Removal of the floxed cre/ERT fusion is required to express downstream genes. Eight founders were generated (TiRP-1-5, TiRP-5-6, TiRP-8/9A, TiRP-8/9B, TiRP-10A, TiRP-10B, TiRP-14 , and TiRP-16) and each contained concatemers of the transgene in head to tail or tail to tail orientations. Cre mediated recombination removes all but one copy of the recombined transgene. In the case of line 14, cre mediated recombination also results in the removal of the polyadenylation site following Trap1a. (J:107175)

Activity:	Tissue activity of this recombinase allele
Driver:	Tyr (mouse) Summary of all recombinase alleles driven by Tyr. Alliance mouse Tyr gene page

List all tumor models in MMHCdb carrying Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:107175 Huijbers IJ, et al., An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res. 2006 Mar 15;66(6):3278-86
All:	1 reference(s)