Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol: Grik4tm1(cre)Mim Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Masayoshi Mishina MGI ID: MGI:3850720 Synonyms: GluRgamma1cre Gene: Grik4  Location: Chr9:42431708-42856296 bp, - strand  Genetic Position: Chr9, 23.8 cM Alliance: Grik4tm1(cre)Mim page

Increased susceptibility to kainate-induced tonic-clonic seizures in Grin1tm1Mim/Grin1tm1Mim Grik4tm1(cre)Mim/Grik4+ mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:144994
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Grik4tm1(cre)Mim expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Grik4 (MGI:95817)   Mutation details: The cre gene was inserted into the translational initiation site of the gene. An frt-flanked neo cassette followed the cre gene. Expression of cre is restricted to hippocampal CA3 pyramidal neurons and does not recapitulate the expression of the endogenous gene, presumably due to the neo cassette insertion. (J:144994)

Activity:	Tissue activity of this recombinase allele
Driver:	Grik4 (mouse) Summary of all recombinase alleles driven by Grik4. Alliance mouse Grik4 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik4 Mutation:	48 strains or lines available

Original:	J:144994 Fukushima F, et al., Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons. PLoS One. 2009;4(1):e3993
All:	1 reference(s)