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Tg(LRRK2)1Cjli
Transgene Detail
Summary
Symbol: Tg(LRRK2)1Cjli
Name: transgene insertion 1, Chenjian Li
MGI ID: MGI:3847810
Synonyms: BAC WT LRRK2, TG-WT-OX, WT-OX
Transgene: Tg(LRRK2)1Cjli  Location: unknown  
Alliance: Tg(LRRK2)1Cjli page
Transgene
origin
Strain of Origin:  FVB/NTac
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LRRK2)1Cjli expresses 1 gene
 
Mutation detailsThe human bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 188 kb BAC containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene with 29 kb upstream of the LRRK2 start codon and 42 kb downstream of the LRRK2 stop codon. Bioinformatics analysis predicted that no other genes are present in the BAC. This BAC was microinjected into fertilized FVB/NTac zygotes. (J:149135)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:149135 Li Y, et al., Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci. 2009 Jun 7;12(7):826-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory