Analysis Tools
growth/size/body
| N |
• mice develop normally and do not exhibit progressive motor behavioral deficits
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Allele Symbol Allele Name Allele ID |
Tg(LRRK2)1Cjli transgene insertion 1, Chenjian Li MGI:3847810 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice develop normally and do not exhibit progressive motor behavioral deficits
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chaperone-mediated autophagy is impaired in primary neuronal cultures as determined by the use of a photoactivatable fluorescent reporter to visualize movement from cytosol to lysosome
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• exogenous and endogenous alpha-synuclein is found associated to lysosomes and organized into irreversible oligomeric complexes in primary neuronal cultures
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• chaperone-mediated autophagy is impaired in primary neuronal cultures as determined by the use of a photoactivatable fluorescent reporter to visualize movement from cytosol to lysosome
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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