Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Fat4tm1.1Hmc
Name:	FAT atypical cadherin 4; targeted mutation 1.1, Helen McNeill
MGI ID:	MGI:3846573
Synonyms:	Fat4-, Fat42E11 deltaflox
Gene:	Fat4  Location: Chr3:38941089-39066134 bp, + strand  Genetic Position: Chr3, 18.72 cM
Alliance:	Fat4tm1.1Hmc page

Germline Transmission:	Earliest citation of germline transmission: J:138247
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and frt flanked PGK-neo cassette were inserted downstream of exon 3 via homologous recombination. Two mutant ES cell lines acquired the two loxP insertion in the targeted gene. This allele is derived from line 2E11 in which targeting occured as expected. Subsequent Cre mediated recombination removed exon 3. (J:138247)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fat4 Mutation:	223 strains or lines available

Original:	J:138247 Saburi S, et al., Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008 Aug;40(8):1010-5
All:	17 reference(s)