Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hdac2tm1.2Rdp
Name:	histone deacetylase 2; targeted mutation 1.2, Ronald DePinho
MGI ID:	MGI:3844984
Synonyms:	HDAC2KO
Gene:	Hdac2  Location: Chr10:36850540-36877885 bp, + strand  Genetic Position: Chr10, 19.44 cM, cytoband B1
Alliance:	Hdac2tm1.2Rdp page

Germline Transmission:	Earliest citation of germline transmission: J:148391
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: LoxP sites were inserted upstream of exon 5 and downstream of exon 6. Mice carrying this allele were crossed with mice expressing cre recombinase in the germline. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of homozygote brain extracts. The same analysis showed that expression of related Hdac1 protein was upregulated. (J:148391)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hdac2 Mutation:	38 strains or lines available

Original:	J:148391 Guan JS, et al., HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009 May 7;459(7243):55-60
All:	3 reference(s)